Spatio-temporal overview of neuroinflammation in an ... - Nature
2019年1月24日 · Low and high scale mapping of the glial activation on brain sections of mice subjected to 30 minutes middle cerebral artery occlusion (MCAO) was correlated with that of the neuronal cell death,...
Oligodendrocyte precursor cells transplantation protects …
2020年1月6日 · To examine whether OPCs had beneficial effect on endothelial cells after MCAO, we performed β-catenin/CD31 double staining. β-catenin was mainly expressed on the cerebral vasculature (Fig. 4a).
Cranial Bone Transport Promotes Angiogenesis, Neurogenesis, and ...
2022年2月9日 · The number of CD31-positive blood vessels in perilesional cortex was significantly increased in MCAO rats treated with CBT, compared with the MCAO group (Figure 3A and 3B). The increased mRNA and protein expression of VEGF (vascular endothelial growth factor) A and Ang (angiotensin)-1 in perilesional brain cortex from MCAO+BT group were also ...
FSAP aggravated endothelial dysfunction and neurological deficits …
2022年1月7日 · a–d Cerebral vasculature was detected and quantified by CD31 (green) immunostaining in the penumbral regions at 3 and 28 days after MCAO. a Representative CD31 immunostaining images, b ...
Enhancement of angiogenesis and neurogenesis by …
2021年8月1日 · The mRNA and protein expression of CD31 were also assessed in the striatum and cortical region to estimate angiogenesis post MCAO. Our findings demonstrate that CM treatment could significantly ameliorate neurological deficits and infarct volume in MCAO rats.
Rarefaction of CD31-immunoreactive endothelium after middle …
CC3-immunoreactive CD31 þ endothelial cells containing fragmented nuclei were detected starting on day 5 after MCAO ( Figure 2 C). It should be noted that our analysis was restricted to the ...
Macrophage depletion reduced brain injury following middle …
2016年2月13日 · Macrophage depletion enhanced the microvessel density in the peri-infarct region of mice brain after MCAO. Photomicrographs show that CD31 + microvessels in the peri-infarct region of the ipsilateral striatum in Vehicle (a), PBS (b), and CLP (c) groups at 14 days after MCAO. Scale bar = 100 μm.
AIM2 deletion enhances blood‐brain barrier integrity in …
2021年6月22日 · To determine whether AIM2 is associated with BBB breakdown after MCAO, we immunofluorescently labeled AIM2 and the endothelial cell marker CD31 in the ischemic penumbra (Figure 1C). AIM2 colocalized with CD31, and the percentage of the CD31 + AIM2 + vascular length with respect to the total CD31 + vascular length was dramatically increased on ...
Dl-3-n-butylphthalide attenuates brain injury caused by cortical ...
2022年1月31日 · Significant reduction in CD31 was detected on the first day after MCAO, whether or not it was accompanied by venous circulatory disturbance. On the third day after the operation, the simple MCAO group presented a prominent improvement in CD31 extremely back to the normal level; however, the EJVO +MCAO group showed a mild increase in CD31.
大鼠局灶性脑缺血后完整、受损、坏死和凋亡的细胞
1998年4月1日 · 大脑中动脉闭塞 (MCAo) 导致脑细胞死亡。 然而，尚未在大鼠中确定 MCAo 后受损脑细胞和炎症细胞的定量。 因此，通过腔内单丝在雄性 Wistar 大鼠中诱导了瞬时 (2 小时) MCAo。