Methionine sulfoximine - Wikipedia
Methionine sulfoximine (MSO, also known as MetSox [1]) is an irreversible glutamine synthetase inhibitor. It is the sulfoximine derivative of methionine with convulsant effects. [2] Methionine sulfoximine is composed of two different diastereomers, which are L-S-Methionine sulfoximine and L-R-Methionine sulfoximine.
Therapeutic effects of methionine sulfoximine in multiple …
Methionine sulfoximine (MSO), a well-characterized inhibitor of glutamine synthetase, displays significant therapeutic benefits in animal models for several human diseases. This amino acid might therefore be a viable candidate for drug development …
L-Methionine-DL-sulfoximine (MSX) | 谷氨酰胺合成酶抑制剂; 惊 …
L-Methionine-DL-sulfoximine (MSX; MSO), a highly specific and irreversible inhibitor of Glutamine synthetase (GS), is also a potent convulsant which metabolically and morphologically primarily affects astroglia. L-Methionine-DL-sulfoximine has been employed to inhibit the Gln-dependent ammonia-stimulated neuronal toxicity in vitro, potentiating ...
L -Methionine sulfoximine 15985-39-4 - MilliporeSigma
L-Methionine sulfoximine (MSX) enhances NH 3 production in seedling leaves wheat, barley, corn and sorghum plants by inhibiting GS activity. MSX increases ornithine decarboxylase activity and decreases the survival rate in a model of transient cerebral ischemia.
Methionine Sulfoximine - an overview | ScienceDirect Topics
Methionine sulfoximine is a rare amino acid that is formed as a byproduct of nitrogen trichloride treatment of flour. Circumstances of Poisoning Agenized flour was extensively used in bread production and cooking for more than 50 years.
L-Methionine sulfoximine | C5H12N2O3S | CID 89034 - PubChem
L-methionine sulfoximine is a methionine sulfoximine in which the amino group has S-stereochemistry. It has a role as a geroprotector and an EC 6.3.1.2 (glutamate -- ammonia ligase) inhibitor. It is a methionine sulfoximine, a L-methionine derivative and a non-proteinogenic L-alpha-amino acid.
Identification of L-Methionine-S-Sulfoximine as the Convulsant …
The convulsant agent methionine sulfoximine inhibits brain glutamine synthetase irreversibly and the inhibitor becomes bound to the active site of the enzyme as methionine sulfoximine phosphate. Only one of the four isomers of methionine sulfoximine, L-methionine- S -sulfoximine, inhibits glutamine synthetase.
Therapeutic effects of methionine sulfoximine in multiple …
2017年3月15日 · Hyperammonemic brain swelling can be treated with methionine sulfoximine, an inhibitor of glutamine synthetase. Inhibiting glutamine synthetase with methionine sulfoximine might be an effective treatment for glutamate excitotoxicity. Methionine sulfoximine reduces an inflammatory immune response
Direct formation and site-selective elaboration of methionine ...
2022年12月12日 · In this article, we report selective methionine sulfoximidation within unprotected polypeptides, and demonstrate selective sulfoximine N–H modification via a Chan–Lam-type oxidative cross coupling 17,18 with boronic acid reagents. The method also serves as a two-step approach to bioconjugation at methionine.
Methionine sulfoximine - DrugBank Online
2018年6月21日 · Methionine sulfoximine DrugBank Accession Number DB14103 Background. Not Available. Type Small Molecule Groups Experimental Structure
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