aminopterin/methotrexate embryofetopathy - National …
Aminopterin/Methotrexate embryofetopathy is a syndrome of developmental anomalies characterized by growth deficiency, facial dysmorphism and skull, limb and neural defects secondary to maternal exposure to aminopterin or methotrexate (MTX) during pregnancy.
Fetal methotrexate syndrome: A systematic review of case reports
2019年8月1日 · We performed a systematic review that yielded 29 cases of (congenital) anomalies after in utero exposure to methotrexate and compared their malformation pattern to that of children and fetuses with congenital anomalies in general.
The effects of methotrexate on pregnancy, fertility and lactation
1999年10月1日 · We examine the effects of MTX with respect to fertility, pregnancy and lactation, based upon information obtained using `Medline' search strategies from 1966 to 1997, hand search through the last ten years of the journal Teratology, source paper references and data from the UK National Teratology Information Service (NTIS) from 1992.
Aminopterin/methotrexate embryofetopathy - Orphanet
A syndrome of developmental anomalies characterized by growth deficiency, facial dysmorphism and skull, limb and neural defects secondary to maternal exposure to aminopterin or methotrexate (MTX) during pregnancy.
Extremity Findings of Methotrexate Embryopathy - PMC
Methotrexate (MTX), a derivative of aminopterin, has been used to treat malignancies, autoimmune diseases, dermatologic conditions, ectopic pregnancies, and voluntary early fetal terminations. 1-3 MTX acts as a folic acid antagonist and disrupts DNA methylation.
Extremity Findings of Methotrexate Embryopathy
2019年9月22日 · Methotrexate (MTX), a derivative of aminopterin, has been used to treat malignancies, autoimmune diseases, dermatologic conditions, ectopic pregnancies, and voluntary early fetal terminations. 1-3 MTX acts as a folic acid antagonist and disrupts DNA methylation.
Fetal aminopterin syndrome (Concept Id: C0432367) - National …
A syndrome of developmental anomalies characterized by growth deficiency, facial dysmorphism and skull, limb and neural defects secondary to maternal exposure to aminopterin or methotrexate (MTX) during pregnancy.
Teratogen update: Methotrexate - Hyoun - Wiley Online Library
2012年3月20日 · A disproportionality analysis of methotrexate and aminopterin case reports and series provides support for pulmonary atresia, craniosynostosis, and limb deficiencies as reported more often than expected in methotrexate-exposed children.
Adult and two children with fetal methotrexate syndrome
The long-term outcome of the fetal aminopterin syndrome has been published in only four adults. We report on a 28-year-old man with fetal methotrexate syndrome and two children with mild manifestations of the syndrome.
Fetal Aminopterin Syndrome | Syndromes: Rapid Recognition …
Methotrexate, which is the methyl derivative of aminopterin, can have the same effect in dosages greater than 10 mg/week. The possible association between this medical condition and in-utero methotrexate exposure has been reported.