Mitochondrial pyruvate carrier - Wikipedia
The mitochondrial pyruvate carriers are composed of: [1] [2] Mitochondrial pyruvate carrier 1; Mitochondrial pyruvate carrier 2; The pyruvate carriers are involved in mitochondrial metabolism but it is possible to compensate for their loss of function. [3] They have been studied for a role in cardiac stress adaption. [4]
Mitochondrial pyruvate carrier 1 - Wikipedia
Mitochondrial pyruvate carrier deficiency (MPYCD) is an autosomal recessive disease due to mutations in the MPC1 gene on chromosome 6q27. It is an inborn error of carbohydrate metabolism that blocks aerobic glycolysis by preventing the transport of pyruvate from the cytosol into the mitochondrion for oxidative phosphorylation; however ...
Mitochondrial pyruvate carrier 2 - Wikipedia
Mitochondrial pyruvate carrier 2 (MPC2) also known as brain protein 44 (BRP44) is a protein that in humans is encoded by the MPC2 gene. [5] [6] [7] It is a member of the Mitochondrial Pyruvate Carrier (MPC) protein family. [8]
The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial ... - MDPI
2020年6月18日 · Import of pyruvate requires the voltage-dependent anion channel (VDAC) to cross the outer mitochondrial membrane (OMM) and the mitochondrial pyruvate carrier (MPC) to cross the inner mitochondrial membrane (IMM).
The long and winding road to the mitochondrial pyruvate carrier
2013年1月23日 · Decades of research have investigated the mitochondrial pyruvate carrier (MPC), all without knowing the encoding gene or genes. These studies range from observational inquiries in general or specific situations to intensive and focused studies on the kinetics and biochemistry of the MPC.
The Role of Mitochondrial Pyruvate Carrier in Neurological …
2024年8月23日 · The mitochondrial pyruvate carrier (MPC) is a specific protein complex located in the inner mitochondrial membrane. Comprising a heterodimer of two homodimeric membrane proteins, mitochondrial pyruvate carrier 1 and mitochondrial pyruvate carrier 2, MPC connects cytoplasmic metabolism to mitochondrial metabolism by transferring pyruvate from ...
2022年3月22日 · In 2012, the molecu-lar-genetic identication of the mitochondrial pyruvate carrier (MPC), a heterodimeric complex composed of protein subunits. MPC1 and MPC2, enabled studies that shed light on the many metabolic and physiological processes regulated by …
The mitochondrial carrier pathway transports non-canonical …
2020年1月6日 · The mitochondrial pyruvate carrier (MPC) plays a central role in energy metabolism by transporting pyruvate across the inner mitochondrial membrane. Its heterodimeric composition and homology to SWEET and semiSWEET transporters set the MPC apart from the canonical mitochondrial carrier family (named MCF or SLC25).
The Mitochondrial Pyruvate Carrier: Has It Been Unearthed at …
2012年8月8日 · The mitochondrial pyruvate carrier (MPC) is essential for several major pathways of carbohydrate, fat, and amino acid metabolism, yet its molecular identity has remained elusive. Two recent papers in Science (Herzig et al., 2012; Bricker et al., 2012) implicate three newly identified inner mitochondrial membrane proteins as MPC components.
The transport of pyruvate, the end product of glycolysis, into mitochondria is an essential process that provides the organelle with a major oxidative fuel. Although the existence of a specific mitochondrial pyruvate carrier (MPC) has been anticipated, its …