MOGAD: How It Differs From and Resembles Other Neuroinflammatory …
2021年2月17日 · Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) is a distinct CNS inflammatory disease with symptoms and imaging findings that overlap other neuroinflammatory disorders. We highlight the imaging characteristics of MOGAD and contrast them with neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS).
MRI features of myelin oligodendrocyte glycoprotein antibody …
2023年7月7日 · Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is a novel inflammatory demyelinating disease of the central nervous system. This study aims to characterize the MRI features of MOGAD and contrast our results with the findings previously described in the literature and its close differential diagnoses.
Radiologic Lag and Brain MRI Lesion Dynamics During Attacks in …
2024年5月6日 · This multicenter study explored the acute dynamics of brain MRI features of MOGAD within a single attack and demonstrated 3 major findings. First, the initial brain MRI can be normal in 10% of attacks despite patients being symptomatic. Second, within a single MOGAD attack, new brain lesions often develop and occasionally resolve.
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD …
2022年6月16日 · A correct diagnosis of MOGAD requires: (1) detection of MOG-IgG in serum and/or CSF with a reliable laboratory assay; and (2) presence of a clinical-MRI phenotype compatible with MOGAD (23, 136). Positivity for MOG-IgG in patients with atypical phenotypes should raise the suspicion for a false positive result, which may have important treatment ...
MOGAD: How It Differs From and Resembles Other Neuroinflammatory …
2021年2月17日 · Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) is a distinct CNS inflammatory disease with symptoms and imaging findings that overlap other neuroinflammatory disorders. We highlight the imaging characteristics of MOGAD and contrast them with neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS).
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD …
2022年6月17日 · Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is the most recently defined inflammatory demyelinating disease of the central nervous system (CNS). Over the last decade, several studies have helped delineate the characteristic clinical-MRI phenotypes of the disease, al …
MS Minute: Myelin Oligodendrocyte Glycoprotein …
The core clinical phenotypes of MOGAD may occur in isolation or as part of a multifocal presentation (eg, simultaneous optic neuritis and myelitis). 3, 5. MRI lesions during acute MOGAD attacks are dynamic. Initial brain or spine MRI findings at symptom onset can be normal in up to 10% of individuals, and therefore repeat imaging should be ...
The influence of MOGAD on diagnosis of multiple sclerosis using MRI
2024年9月3日 · The new MOGAD criteria 35 do not allow a diagnosis of MOGAD in patients with a borderline MOG-IgG test and a normal MRI scan at the beginning of a brain or spinal cord attack, as this...
髓鞘少突胶质细胞糖蛋白抗体相关疾病的临床特征和诊断 - UpToDate
髓鞘少突胶质细胞糖蛋白抗体相关疾病 (myelin oligodendrocyte glycoprotein antibody-associated disease, MOGAD)是一种CNS炎症性疾病，特征为免疫介导的脱髓鞘发作，主要累及视神经、大脑和脊髓，好发于儿童。 本文将总结MOGAD的流行病学、发病机制、临床表现和诊断，治疗和预后参见其他专题。 (参见 “髓鞘少突胶质细胞糖蛋白抗体相关疾病的治疗和预后”) 髓鞘少突胶质细胞糖蛋白 (myelin oligodendrocyte glycoprotein, MOG)存在于少突胶质细胞表面，过去认为这是多 …
Clinical and neuroimaging findings in MOGAD–MRI and OCT
Typical MRI findings of ON in MOGAD are long lesions in the anterior part of the optic nerve with periorbital enhancement and often bilateral affection . Spinal cord lesions in MOGAD can be visualized using MRI typically showing LETM affecting mainly the grey matter, as seen as an ‘H-sign’ on the axial plane [ 43 ].
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