Targeting ferroptosis by poly(acrylic) acid coated Mn3O4 nanoparticles …
2023年11月21日 · Herein, we report a simple and one-pot synthesis of ultrasmall poly (acrylic) acid coated Mn 3 O 4 nanoparticles (PAA@Mn 3 O 4 -NPs, PMO), which perform multiple antioxidant enzyme-mimicking...
Photothermia at the nanoscale induces ferroptosis via nanoparticle ...
2023年8月2日 · In these nanoparticles, Fe (II) is sequestered within the crystal structure, and for it to become active, the nanoparticles have to be degraded. Eliciting such a response could then lead to...
Targeting ferroptosis opens new avenues for the development of …
2023年9月21日 · Targeting ferroptosis using nanoparticles. Compared to small-molecule compounds, ferroptosis-inducing nanoparticles have been suggested to have a better preclinical profile.
Nanoparticle-induced ferroptosis: detection methods, mechanisms and ...
However, it is challenging to differentiate nanoparticle-induced ferroptosis from other types of cell deaths (e.g., apoptosis, pyroptosis, and necrosis), elucidate the detailed mechanisms and identify the key property of nanoparticles responsible for ferroptotic cell deaths.
Ultra-small Janus nanoparticle-induced activation of ferroptosis …
2024年6月1日 · Here, MnFe 2 O 4 @NaGdF 4 @NLG919@HA (MGNH) nanocomplex with tumor-specific targeting and TME response is constructed to overcome immunosuppressive tumor microenvironment (TME) to potentiate the curative effect of ferroptosis by coupling the immune checkpoint indoleamine 2,3-dioxygenase (IDO) inhibitor, NLG919, and …
Magnetic nanoparticles for ferroptosis cancer therapy with …
2024年2月1日 · Recent advances in the use of magnetic nanoparticles for ferroptosis cancer nanomedicine are summarized. The advantages of image-guided ferroptosis cancer nanomedicine are overviewed. The rational design and fabrication of magnetic nanoparticles to enhance local ferroptosis induction are described.
Mechanisms and therapeutic targets of ferroptosis: Implications …
2024年7月1日 · Nanomedicines hold considerable promise for the diagnosis and management of diseases based on ferroptosis therapy. Ferroptosis is a nonapoptotic form of cell death and differs considerably from the well-known forms of cell death in terms of …
Spatially Asymmetric Nanoparticles for Boosting Ferroptosis in …
2024年1月17日 · Herein, we developed a spatially asymmetric nanoparticle, Fe 3 O 4 @DMS&PDA@MnO 2-SRF, for enhanced ferroptosis. It consists of two subunits: Fe 3 O 4 nanoparticles coated with dendritic mesoporous silica (DMS) and PDA@MnO 2 (PDA: polydopamine) loaded with sorafenib (SRF).
Targeting Ferroptosis by Polydopamine Nanoparticles Protects …
2021年11月3日 · Here, we developed polydopamine nanoparticles (PDA NPs) as a new type of ferroptosis inhibitor for cardioprotection. The PDA NPs features intriguing properties in inhibiting Fe 2+ accumulation and restoring mitochondrial functions in H9c2 cells.
Ferritin‐Hijacking Nanoparticles ... - Wiley Online Library
2022年10月10日 · With laser irradiation, the activated Ce6 in nanoparticles potently generates reactive oxygen species (ROS) surrounding ferritin. Abundant ROS not only helps to destroy the iron storage protein and activate endogenous ferroptosis but also directly kill tumor cells.