p62/SQSTM1-droplet serves as a platform for autophagosome
2021年1月4日 · In this report, we describe the properties of endogenous p62-bodies, the effect of autophagosome biogenesis on these bodies, and the in vivo significance of their turnover. p62 …
Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in …
In this review, we highlight recent advances in understanding the role of p62 in coordinating the ubiquitin-proteasome system and autophagy. We also discuss positive and negative effects of …
p62, an autophagy hero or culprit? | Nature Cell Biology
2010年2月21日 · Toxic aggregate-prone proteins, invading microorganisms and damaged organelles are cleared from the cytoplasm by autophagy, a process that involves their …
p62 links the autophagy pathway and the ubiqutin–proteasome …
2016年12月13日 · An increasing body of evidence indicates that ubiquitinated cargoes are important markers of degradation. p62, a classical receptor of autophagy, is a multifunctional …
The Pathways Underlying the Multiple Roles of p62 in …
p62 regulates and links central pathways in inflammation and cancer development. p62 is an important cargo receptor for autophagy and mitophagy and thus inhibits inflammasome …
ZZ-dependent regulation of p62/SQSTM1 in autophagy - Nature
2018年10月22日 · We show that binding of p62 ZZ to Nt-R substrates stimulates p62 aggregation and macroautophagy and is required for autophagic targeting of p62. p62 is essential for …
p62 links the autophagy pathway and the ubiqutin–proteasome …
An increasing body of evidence indicates that ubiquitinated cargoes are important markers of degradation. p62, a classical receptor of autophagy, is a multifunctional protein located …
S -acylation of p62 promotes p62 droplet recruitment into ... - Cell …
2023年10月5日 · p62 is a well-characterized autophagy receptor that recognizes and sequesters specific cargoes into autophagosomes for degradation. p62 promotes the assembly and …
p62 links the autophagy pathway and the ubiqutin-proteasome ... - PubMed
2016年12月13日 · An increasing body of evidence indicates that ubiquitinated cargoes are important markers of degradation. p62, a classical receptor of autophagy, is a multifunctional …
Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 ...
2023年2月21日 · In this study, we showed that E3 ligase Smurf1 enhanced Nrf2 activation and promoted autophagy by increasing p62 phase separation capability. Specifically, the …