Targeting fibrosis: mechanisms and clinical trials | Signal ...
Jun 30, 2022 · CTGF signaling pathway. CTGF is a secreted peptide and has been considered as a novel PDGF-related growth factor regulating the proliferation and chemotaxis of fibroblasts …
CTGF is a central mediator of tissue remodeling and fibrosis and …
Jun 6, 2012 · CTGF is a secreted matricellular protein with very complex biology. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, …
Essential role of connective tissue growth factor (CTGF) in ...
May 8, 2018 · In this study, we investigated the role of CTGF in TGF-β-induced extracellular matrix production and myofibroblast transdifferentiation in Graves’ orbital fibroblasts. By …
Connective tissue growth factor: a fibrogenic master switch in …
Aug 6, 2008 · The data suggest CTGF as a multifaceted regulatory protein in fibrosis, which offers important translational aspects for diagnosis and follow-up of hepatic fibrogenesis and as a …
PDGF signaling pathway in hepatic fibrosis pathogenesis and ...
Blocking PDGF signaling inhibits HSC proliferation and ameliorates liver fibrogenesis (12). Clinical studies have additionally confirmed that excessive activation of PDGF and its downstream …
PDGF Promotes Dermal Fibroblast Activation via a Novel …
MCHR1 silencing in NHDF reduced PDGF-BB signaling. In summary, MCHR1 promoted the fibrotic response in NHDF through modulation of TGFβ1 and CTGF production, intracellular …
PDGF signaling pathway in hepatic fibrosis pathogenesis and ...
Sep 27, 2017 · The platelet-derived growth factor (PDFG) signaling pathway exerts persistent activation in response to a variety of stimuli and facilitates the progression of hepatic fibrosis. …
Targeting CTGF, EGF and PDGF pathways to prevent progression …
Oct 14, 2014 · TGF-β is generally considered to be the driving force behind fibrotic processes in the kidney; however, CTGF, PDGFR and EGFR signalling pathways have also been identified …
Therapeutic strategies to target connective tissue growth factor in ...
Jan 1, 2024 · Increased expression of CTGF has been observed in fibrotic lungs and inhibiting CTGF signaling has been shown to suppress lung fibrosis in several animal models. Thus, the …
PDGF in organ fibrosis - PubMed
Stromal mesenchymal cells express both PDGF receptors (PDGFR) α and β, activation of which drives proliferation, migration and production of extracellular matrix, i.e. the principal …