Stage 4 Pancreatic Cancer: Metastatic Treatment and Survival Rate
Patients with stage 4 pancreatic cancer may experience various symptoms compared to earlier signs of the disease. Symptoms may also vary based on where the cancer has spread, though it most commonly spreads to the liver. General metastatic pancreatic cancer symptoms may include: When cancer has spread into the bones, symptoms may include:
Single cell transcriptomic analyses implicate an ... - Nature
2023年8月23日 · Here, we present the single-cell transcriptomic landscape of synchronously resected PDAC primary tumors and matched liver metastases. We perform comparative analysis on both cellular...
How Pancreatic Cancer Cells Target the Liver
2019年3月6日 · Researchers at the University of Pennsylvania seek to understand how – and why – pancreatic cancer cells spread to the liver. New donor-funded research published today in the journal Nature describes signals that prepare the liver in …
Pancreatic cancer and liver metastases: state of the art
Synchronous resection of both the primary tumour as well as the liver metastases may be beneficial and improves the outcome. Keywords: Liver metastasis; Palliative chemotherapy; Pancreatic adenocarcinoma; Synchronous resection. Pancreatic cancer is still one of the most aggressive oncological diseases with a 5-year mortality rate below 10%.
Pancreatic cancer and liver metastases: state of the art
2016年11月10日 · Recent findings suggest that some patients with non-resectable diseases initially have survival rates as good as those with initially resectable disease when they are able to undergo surgical resection. Synchronous resection of both the primary tumour as well as the liver metastases may be beneficial and improves the outcome.
Multi-parametric atlas of the pre-metastatic liver for ... - Nature
2024年6月28日 · Metastasis occurs frequently after resection of pancreatic cancer (PaC). In this study, we hypothesized that multi-parametric analysis of pre-metastatic liver biopsies would classify...
Molecular mechanisms of pancreatic cancer liver metastasis
2024年1月26日 · Results: Through a series of algorithmic filters, we identified PAK2 as a key gene promoting pancreatic cancer liver metastasis. GSVA analysis elucidated the activation of the TGF-beta signaling pathway by PAK2 to promote the occurrence of liver metastasis.
Efferocytosis reprograms the tumor microenvironment to promote ...
2024年2月14日 · Our findings reveal how hard-wired functions of macrophages in tissue repair contribute to liver metastasis and identify potential targets for prevention of pancreatic ductal adenocarcinoma...
Oncologic resection of pancreatic cancer with isolated liver metastasis ...
Results: Forty-seven patients underwent curative-intent surgery for metastatic PDAC to the liver between 2000 and 2019. Median OS was 21.9 months from diagnosis. Fourteen patients underwent unplanned resection of radiographically occult liver metastasis during pancreatectomy with median OS of 8.7 months.
The identification of liver metastasis- and prognosis-associated …
2022年4月27日 · Pancreatic ductal adenocarcinoma (PDAC) is an often fatal malignancy with an extremely low survival rate. Liver metastasis, which causes high mortality, is the most common recurring metastasis for PDAC. However, the mechanisms underlying this liver metastasis and associated candidate biomarkers are unknown.