Pathways of Intracellular Signal Transduction - The Cell - NCBI …
The active Ca 2+ /calmodulin complex binds to a variety of target proteins, including Ca 2+ /calmodulin-dependent protein kinases. Ca 2+ is an extremely common second messenger, and it is important to note that IP 3 -mediated release of Ca 2+ from the endoplasmic reticulum is not the only mechanism by which the intracellular concentration of Ca ...
Calmodulin - Wikipedia
Many of the proteins that calmodulin binds are unable to bind calcium themselves, and use calmodulin as a calcium sensor and signal transducer. Calmodulin can also make use of the calcium stores in the endoplasmic reticulum, and the sarcoplasmic reticulum.
Calmodulin and calmodulin-like proteins in plant calcium signaling
2011年12月1日 · Calmodulin (CaM) is a primary calcium sensor in all eukaryotes. It binds calcium and regulates the activity of a wide range of effector proteins in response to calcium signals. The list of CaM targets includes plant-specific proteins …
Calcium Signaling - Cell Press
2007年12月14日 · Calcium ions (Ca 2+) impact nearly every aspect of cellular life. This review examines the principles of Ca 2+ signaling, from changes in protein conformations driven by Ca 2+ to the mechanisms that control Ca 2+ levels in the cytoplasm and organelles.
The Role of Calmodulin and Related Proteins in Plant Cell
2014年11月18日 · Calmodulin (CaM), the most important eukaryotic CBP, senses and responds to fluctuations in intracellular Ca 2+ levels by binding to this ubiquitous second messenger, and transducing given Ca 2+ signatures that differentially activate distal effector (target) proteins regulating a broad range of biochemical responses.
Calmodulin influences MAPK signaling by binding KSR1
2021年3月23日 · The mitogen-activated protein kinase (MAPK) pathway is a vital signal transduction cascade that regulates cell growth, cell proliferation, cell differentiation, apoptosis, and stress responses (1, 2). MAPKs are evolutionally conserved proteins that respond to diverse stimuli and link extracellular signals to fundamental cellular processes.
Calmodulin and Signal Transduction | ScienceDirect
Calmodulin and Signal Transduction focuses on emerging themes in the molecular mechanisms of calcium signal transduction through calmodulin-regulated pathways. It provides the reader with selected examples and experimental precedents that underlie current models of cell regulation through calmodulin-regulated pathways and their linkage with ...
Calmodulin binding transcription activators: An interplay between ...
2021年1月1日 · In the signal transduction pathway, calmodulin (among the other molecules) lies next to the secondary messenger, calcium. As the name indicates, calmodulins are highly conserved Calcium-Modulated proteins, identified and characterized in all eukaryotes including plants ( Klee and Vanaman, 1982 ; Means et al., 1982 ).
Calmodulin as a versatile calcium signal transducer in plants
2001年12月21日 · Ca 2+ -binding proteins (sensors) play a key role in decoding Ca 2+ signatures and transducing signals by activating specific targets and pathways. Calmodulin is a Ca 2+ sensor known to modulate the activity of many mammalian proteins, whose targets in plants are now being actively characterized.
Calcium-Calmodulin-Calcineurin Signaling: A Globally …
2019年10月9日 · In this Review, Park et al. provide an overview of the calcium-calmodulin-calcineurin signaling pathways in eukaryotic microbial pathogens, with a focus on fungal pathogens and parasitic protists. They highlight both the conserved and unique aspects of this important pathway and explore their potential role as therapeutic targets against such ...