Phosphoinositide Pathway | Cell Signaling Technology
Phosphoinositides are universal signaling entities that regulate cell activities through direct interaction with membrane proteins (e.g., ion channels, GPCRs) or through membrane recruitment of cytosolic proteins containing domains that directly bind phosphoinositides, such as pleckstrin homology (PH), FYVE, WD40 repeats, FERM, PTB, and PDZ doma...
磷酸肌醇通路 | Cell Signaling Technology
Discover the phosphoinositide pathway's role in cellular signaling and membrane dynamics. Click here to read more about PI signaling here.
Phosphoinositides as membrane organizers | Nature Reviews …
2022年5月19日 · On the endocytic and exocytic routes, phosphoinositides direct the inward and outward flow of membrane as vesicular traffic is coupled to the conversion of phosphoinositides. Moreover, recent...
A phosphoinositide signalling pathway mediates rapid lysosomal …
2022年9月7日 · Here, using an unbiased proteomic approach, we show that LMP stimulates a phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway for rapid lysosomal repair.
The phosphoinositide 3-kinase pathway - PubMed
2002年5月31日 · The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted.
Targeting the phosphoinositide 3-kinase pathway in cancer
The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and...
Understanding phosphoinositides: rare, dynamic, and essential …
Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically all …
Great Expectations for PIP: Phosphoinositides as ... - Cell Press
2009年1月20日 · A second, very well-studied phosphoinositide signaling pathway results from the activation of PI 3-kinases (PI3Ks). Downstream of stimulation by growth factors, hormones, or other cellular signals, PI3Ks phosphorylate PI(4,5)P 2 and PI(4)P to produce PI(3,4,5)P 3 and PI(3,4)P 2, respectively. These lipids then activate the downstream protein ...
A phosphoinositide signalling pathway mediates rapid lysosomal …
Here, using an unbiased proteomic approach, we show that LMP stimulates a phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway for rapid lysosomal repair. Upon LMP, phosphatidylinositol-4 kinase type 2α (PI4K2A) accumulates rapidly on damaged lysosomes, generating high levels of the lipid messenger ...
The Phosphoinositide 3-Kinase Pathway | Science - AAAS
2002年5月31日 · The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted.