Potassium channels and pain: present realities and future …
2004年10月1日 · Four families of potassium channels with different structures, functional characteristics and pharmacological sensitivity, are distinguished in neurons: voltage-gated (K …
Potassium channels and pain: present realities and future ... - PubMed
2004年10月1日 · Four families of potassium channels with different structures, functional characteristics and pharmacological sensitivity, are distinguished in neurons: voltage-gated …
10 Potassium Channels and Pain
2018年7月10日 · Potassium channels are expressed in almost all cells of the body, where they are essential for the cellular homeostasis of K +, which plays a major role in many cellular …
Chronic pain as a manifestation of potassium channel-complex ...
Autoantibodies targeting voltage-gated potassium channel (VGKC) complexes cause a spectrum of neuronal hyperexcitability disorders. We investigated pain as a manifestation of VGKC …
Distinct potassium channels on pain-sensing neurons - PNAS
To better understand the molecular physiology and pharmacology of sensory neurons, and to identify specific Kv channels that may represent potential targets for therapeutics to treat …
Potassium channels and pain: present realities and future opportunities ...
2004年10月1日 · Chronic pain is associated with abnormal excitability of the somatosensory system and remains poorly treated in the clinic. Potassium (K +) channels are crucial …
Role of leak potassium channels in pain signaling - ScienceDirect
2015年10月1日 · In this review, we describe evidence for the roles of TASK1, TASK3, TREK1, TREK2, TRAAK and TRESK channels in pain signaling and behavior. Furthermore, we …
Inflammation differentially controls transport of depolarizing Nav ...
The burden of pain is immense, and current treatments are often ineffective and addictive. Activity in pain-sensing neurons is promoted by proexcitatory (Na V) channels and inhibited by …
Neuropathic pain and Kv7 voltage-gated potassium channels: The ... - PubMed
In this review, we highlight the loss of function of Kv7 voltage-gated potassium as a mechanism of neuropathic pain and the potential use of Kv7 channel activator as subsequent treatment. …
Potassium channels as a potential therapeutic target for …
Recent studies in various pain models identified the voltage-gated KCNQ/Kv7 channel (M-current) opener [19-21] and alterations in either calcium-activated (K Ca) or ATP-sensitive potassium …