Pyruvate Metabolism | Pathway - PubChem
2019年5月30日 · Pyruvate is an intermediate compound in the metabolism of fats, proteins, and carbohydrates. It can be formed from glucose via glycolysis or the transamination of alanine. It can be converted into Acetyl-CoA to be used as the primary energy source for the TCA cycle, or converted into oxaloacetate to replenish TCA cycle intermediates.
Pyruvic acid - Wikipedia
Pyruvic acid (CH 3 COCOOH) is the simplest of the alpha-keto acids, with a carboxylic acid and a ketone functional group. Pyruvate, the conjugate base, CH 3 COCOO −, is an intermediate in several metabolic pathways throughout the cell.
KEGG PATHWAY: Pyruvate metabolism
M00307 Pyruvate oxidation Energy metabolism Carbon fixation M00168 CAM (Crassulacean acid metabolism), dark M00169 CAM (Crassulacean acid metabolism), light M00172 C4-dicarboxylic acid cycle, NADP - malic enzyme type M00579 Phosphate acetyltransferase-acetate …
The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial ... - MDPI
2020年6月18日 · Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria is through the recently identified mitochondrial pyruvate carrier (MPC).
5.3B: Pyruvic Acid and Metabolism - Biology LibreTexts
2022年12月24日 · Pyruvate is the output of the anaerobic metabolism of glucose known as glycolysis. Pyruvate can be converted into carbohydrates via gluconeogenesis, to fatty acids or energy through acetyl-CoA, to the amino acid alanine, and to ethanol.
Role of pyruvate in maintaining cell viability and energy …
2021年9月23日 · Our findings suggest that exogenous pyruvate plays a pivotal role in maintaining glycolysis–TCA cycle flux and ATP production under high-glucose conditions by suppressing PARP activity.
Regulation of pyruvate metabolism and human disease
2013年12月21日 · This review will discuss the enzymes regulating major aspects of pyruvate metabolism, their structures, and the biochemical bases for the reactions they catalyze, the roles dysfunctional forms play in causing human disease, and major diseases for which aberrant pyruvate metabolism is a prominent characteristic.
Pyruvate Metabolism | Pathway - PubChem
2019年5月30日 · The metabolism of pyruvate begins with its biosynthesis which can happen through 5 different sets of reactions. A) Lactaldehyde reacts with an NADPH dependent methylglyoxal reductase results in the release of a pyruvaldehyde. Pyruvaldehyde reacts with glutathione through a lactylglutathione lyase resulting in the release of s-lactoylglutathione.
1.13: Pyruvate Oxidation and the TCA Cycle - Biology LibreTexts
Oxidation of Pyruvate and the TCA Cycle. Overview of Pyruvate Metabolism and the TCA Cycle. Under appropriate conditions, pyruvate can be further oxidized. One of the most studied oxidation reactions involving pyruvate is a two part reaction involving NAD + and molecule called co-enzyme A, often abbreviated simply as "CoA". This reaction ...
Pyruvate metabolism | Pathway - PubChem
2019年1月17日 · Pyruvate sits at an intersection of key pathways of energy metabolism. It is the end product of glycolysis and the starting point for gluconeogenesis and can be generated by the transamination of alanine.