Rho GTPase signalling pathways in the morphological changes …
2002年4月25日 · Recent research has highlighted the importance of Rho GTPase signalling pathways to these changes in cellular architecture. In this review, we will discuss how these …
Rho signals to cell growth and apoptosis - PubMed
2001年4月10日 · In this review, an attempt to briefly integrate recent findings in transcriptional regulation by Rho GTPases in the context of carcinogenesis and metastasis as well as …
Rho kinase in the regulation of cell death and survival - PMC
Inhibition of Rho or ROCK results in activation of caspases 3, 8 and 9, and glioma cell apoptosis . Treatment of human umbilical vein endothelial cells with ROCK inhibitors Y-27632 and HA …
Rho signals to cell growth and apoptosis - ScienceDirect
2001年4月10日 · Tumors generated by stable, Rho-transformed cell lines displayed a high apoptotic index, suggesting that Rho GTPases could be triggering signals that ultimately lead …
Rho family GTPases: key players in neuronal development, …
Rho activates a downstream ROCK/PTEN pathway that indirectly inactivates the pro-survival protein Akt to suppress neuronal survival. Rho can also function to provoke apoptosis via …
Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell …
Rho-associated kinase (Rho-kinase/ROCK/ROK) is an effector of the small GTPase Rho and belongs to the AGC family of kinases. Rho-kinase has pleiotropic functions including the …
Rho Kinase Proteins—Pleiotropic Modulators of Cell Survival and Apoptosis
Rho kinase (ROCK) proteins are Rho-GTPase activated serine/threonine kinases that function as modulators of actin-myosin cytoskeletal dynamics via regulation of Lin11, Isl-1 & Mec-3 …
Atypical Rho GTPases Have Roles in Mitochondrial Homeostasis and Apoptosis
These data indicate a novel role for Rho-like GTPases in mitochondrial homeostasis and apoptosis. Small GTPases have been shown to be pivotal signaling intermediates in cell …
Rho kinase regulates fragmentation and phagocytosis of apoptotic …
2006年1月1日 · Here, we show that COS-7 cells fragment into a number of small apoptotic bodies during apoptosis; treating with ROCK inhibitors (Y-27632 or H-1152) prevents fragmentation. …
Hijacking Rho GTPases by protein toxins and apoptosis: molecular ...
2003年4月16日 · Rho GTPases control the activation of NF- κ B, which is involved in the expression of antiapoptotic proteins and mediates immunological responses as well. Here, we …