RhoA drives actin compaction to restrict axon regeneration and ...
2021年11月3日 · In response to extracellular inhibitors, neuronal RhoA restricts axon regeneration by activating myosin II to compact actin and, thereby, restrain microtubule protrusion. However, astrocytic RhoA restricts injury-induced astrogliosis through myosin II independent of microtubules by activating Yes-activated protein (YAP) signaling.
In response to extracellular inhibitors, neuronal RhoA restricts axon regeneration by activating myosin II to compact actin and, thereby, restrain microtubule protrusion. However, astrocytic RhoA restricts injury-induced astrogliosis through myosin II in-dependent of microtubules by activating Yes-activated protein (YAP) signaling.
Untangling the role of RhoA in the heart: protective effect and ...
2024年8月9日 · Activation of RhoA induces polymerization of G-actin to form F-actin filaments, freeing MRTF-A to translocate to the nucleus, and this triggers activation of SRF target genes that are...
Pulses of RhoA signaling stimulate actin polymerization and flow …
2024年1月22日 · Positive and negative feedbacks cause RhoA and myosin II activities to pulse. These pulses of RhoA signaling stimulate actin polymerization at the tip of the protrusions and myosin-II-dependent actin flow and protrusion retraction at the base of the protrusions and deform the basement membrane underneath the migrating primordium.
RhoA Proteolysis Regulates the Actin Cytoskeleton in Response to ...
2016年12月19日 · The small GTPase RhoA regulates the actin cytoskeleton to affect multiple cellular processes including endocytosis, migration and adhesion. RhoA activity is tightly regulated through several mechanisms including GDP/GTP cycling, phosphorylation, glycosylation and prenylation.
Regulation of RhoA GTPase and various transcription factors in the RhoA ...
As the role of RhoA in regulating actin-filament formation and myosin-actin interaction has been well described, in this review we focus on the transcriptional activity of RhoA and also the regulation of RhoA message itself.
The DIAPH3 linker specifies a β-actin network that maintains RhoA …
2024年6月19日 · β-actin maintains RhoA at the furrow. The localization of RhoA-GTP, the active form of RhoA, to the future site of furrow ingression, is considered a crucial early event driving cytokinesis...
Patterning of the cell cortex by Rho GTPases
2024年1月3日 · The Rho GTPases — RHOA, RAC1 and CDC42 — are small GTP binding proteins that regulate basic biological processes such as cell locomotion, cell division and morphogenesis...
RhoA, a Rho GTPase and regulator of actin-based ... - Cytoskeleton
RhoA is a 22 kDa small GTPase, a member of the Ras super-family and Rho sub-family of GTPases, that upon activation by a guanine nucleotide exchange factor (GEF), is essential in regulating actin cytoskeletal re-arrangement as a part of a signal transduction pathway transducing extracellular signals (activation of cell surface receptors and ...
Rho GTPases and their role in organizing the actin cytoskeleton
2011年3月1日 · Once activated, Rho GTPases bind to a variety of effectors, including protein kinases (Zhao and Manser, 2005) and some actin-binding proteins. These directly or indirectly affect the local assembly or disassembly of filamentous (F)-actin. The pathways downstream of Rho that impinge on actin are the subject of this Cell Science at a Glance article.