重要综述！细胞信号传导蛋白——Rho GTPases - 知乎
2024年2月19日 · Rho GTPases通过调节细胞骨架重塑、细胞迁移、细胞黏附、细胞极化和基因转录等过程参与细胞生物学的多个方面。在这篇综述中，作者提出并讨论了Rho GTPases的自组织能力，即直接从低阶状态过渡到高阶状态。也讨论Rho GTPase的自组织模式形成对细胞功能的优势。
Rho family of GTPases - Wikipedia
The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic kingdoms, including yeasts and some plants.
Regulating Rho GTPases and their regulators - Nature
2016年6月15日 · Rho GTPases, which cycle between a GTP-bound active form and a GDP-bound inactive form, regulate cytoskeletal and cell adhesion dynamics and thus are crucial for the coordination of cell...
Patterning of the cell cortex by Rho GTPases
2024年1月3日 · The Rho GTPases — RHOA, RAC1 and CDC42 — are small GTP binding proteins that regulate basic biological processes such as cell locomotion, cell division and morphogenesis by promoting...
The RHO Family GTPases: Mechanisms of Regulation and Signaling
A characteristic region of RHO family GTPases is the insert helix (amino acids 124–136, RHOA numbering), which may play a role in effector activation and downstream processes .
RHO GTPases: from new partners to complex immune syndromes
2021年2月5日 · In this Review, we describe the recent discovery of atypical modulators and partners of RHO GTPases, which bring an additional layer of regulation and plasticity to the control of RHO GTPase...
Protocol for structural and biochemical analyses of RhoA GTPase
2021年6月18日 · RhoA is a well characterized member of the Rho GTPase family, which is a sub-family of the Ras superfamily of small GTPases. The conformational changes underlying activation and regulation of RhoA and related small GTPases have been an area of great interest to molecular biologists.
Rho family GTPases: key players in neuronal development, …
The Rho family of GTPases belongs to the Ras superfamily of low molecular weight (∼21 kDa) guanine nucleotide binding proteins. The most extensively studied members are RhoA, Rac1, and Cdc42. In the last few decades, studies have demonstrated that ...
Molecular mechanism of regulation of RhoA GTPase by …
2024年1月2日 · Rho-specific guanine nucleotide dissociation inhibitors (RhoGDIs) play a crucial role in the regulation of Rho family GTPases. They act as negative regulators that prevent the activation of Rho GTPases by forming complexes with the inactive GDP-bound state of GTPase.
Rho GTPases in cell biology | Nature
2002年12月12日 · These small, monomeric GTPases, which number over 60 in mammals, fall into five major groups: Ras, Rho, Rab, Arf and Ran. This review focuses specifically on Rho GTPases, emphasizing the...