Potential role of RhoA GTPase regulation in type interferon …
Jan 20, 2024 · RhoA promotes STAT-1 phosphorylation by type I IFN. The two serine-threonine kinases ROCK1 and ROCK2 are important downstream effectors of Rho GTPases that phosphorylate downstream signaling intermediates. RhoA activation is known to induce the tyrosine phosphorylation of the signal transducer and …
Patterning of the cell cortex by Rho GTPases
Jan 3, 2024 · The Rho GTPases — RHOA, RAC1 and CDC42 — are small GTP binding proteins that regulate basic biological processes such as cell locomotion, cell division and morphogenesis by promoting...
Feedback regulation through myosin II confers robustness on RhoA …
Sep 14, 2015 · Active RhoA is found at the apical ring of the ZA (refs 7, 10), forming a micrometre-scale zone of signalling that is well located to coordinate adhesion and contractility. Consistent with this,...
RHOA
Dec 19, 2023 · The RAS homologous (RHO) small guanosine triphosphatases (GTPases; such as RHOA and RAC1) function as signaling nodes that relay extracellular signals to cytoplasmic signaling networks that control diverse cellular processes (1 – 4).
The RhoA GTPase regulates Type I Interferon Signaling in
Sep 20, 2023 · Our study shows that RhoA positively regulates the activation of the type I IFN response pathway. Reducing the expression level of RhoA inhibits the abnormal activation of the type I IFN system, and the RhoA/ROCK inhibitor Y27632 decreases aberrant type I IFN signaling in SLE PBMCs, suggesting the p …
RhoA-ROCK2 signaling possesses complex pathophysiological …
Oct 14, 2024 · RhoA is overexpressed in cancer and promotes cancer progression via RhoA/ROCK2 signaling pathway. RhoA and its downstream effectors Rock2, myosin II, LIMK, and cofilin play critical roles during G1-S phase progression by regulating the expression of cell cycle proteins p21 and cyclin D1.
Fine modulation of RhoA signal amplitude reveals that submaximal levels of RhoA activity preferentially induce focal adhesion disassembly through selective activation of Src kinase, suggesting that amplitude of a single signal can produce distinct cell outcomes.
Potential role of RhoA GTPase regulation in type interferon …
Jan 20, 2024 · Our study shows that RhoA positively regulates the activation of the type I IFN response pathway. Reducing the expression level of RhoA inhibits the abnormal activation of the type I IFN system, and the RhoA/ROCK inhibitor Y27632 decreases aberrant type I IFN signaling in SLE PBMCs, suggesting the p …
RhoA as a Key Regulator of Innate and Adaptive Immunity - MDPI
Jul 17, 2019 · This review aims to highlight the functional role of the prototypic GTPase RhoA and of components of the RhoA signaling cascade for innate immune cell types of the myeloid hematopoietic lineage that act as “sentinel” cells to detect and directly eliminate pathogens, comprising neutrophils, monocytes/macrophages, and conventional dendritic ...
Optical regulation of endogenous RhoA reveals selection of …
Jul 12, 2022 · Ju et al. develop photoswitchable RhoA GEF that enables rheostatic control of endogenous RhoA activity. Fine modulation of RhoA signal amplitude reveals that submaximal levels of RhoA activity preferentially induce focal adhesion disassembly through selective activation of Src kinase, suggesting that amplitude of a single signal can produce ...