Pharmacokinetics of roxithromycin (RU 965) - PubMed
This report contains the findings of five studies performed to evaluate the pharmacokinetics of roxithromycin (RU 965), a new macrolide antibiotic. Roxithromycin was given as 150- and 300-mg film-coated tablets.
Roxithromycin: a pharmacokinetic review of a macrolide
In humans, roxithromycin is rapidly absorbed from the gastrointestinal tract producing peak levels (Cmax) within 2 h. The drug is eliminated with a half-life (T1/2) of about 10 h. Roxithromycin is not extensively metabolized.
Roxithromycin. A review of its antibacterial activity, …
Roxithromycin has a pharmacokinetic profile that is characterised by excellent enteral absorption achieving high concentrations in most tissues and body fluids.
Macrolide pharmacokinetics and dose scheduling of roxithromycin
INTRODUCTION the 150- and 300-mg single-dose pharmacokinetics of roxithromycin, and thus evaluate the suitability of a 300-mg once-a-day dosing schedule of roxithromycin as compared with 150 mg twice daily.
Macrolide pharmacokinetics and dose scheduling of roxithromycin …
1992年5月1日 · The 150- and 300-mg single-dose pharmacokinetics of roxithromycin were investigated in 12 healthy subjects in a crossover study. Serum concentrations were determined by high-performance liquid chromatography (HPLC) and microbiologic assay (MA).
Roxithromycin | Drugs - Springer
2012年10月23日 · Killing curve studies using conditions simulating serum pharmacokinetics show roxithromycin to be rapidly bactericidal against S. pneumoniae, producing a kill rate which exceeded those of erythromycin, doxycycline and ofloxacin.
Antimicrobial Activity, Pharmacokinetics and Clinical Use of Roxithromycin
2012年10月26日 · Roxithromycin is an orally administered erythromycin derivative that has improved absorption, bioavailability, tolerability and clinical efficacy compared with the parent drug.
Pharmacokinetics and Metabolism of Macrolides - ScienceDirect
2003年1月1日 · Pharmacokinetics of roxithromycin in renal and hepatic failure and drug interactions
Roxithromycin | Drugs - Springer
2012年12月11日 · Roxithromycin is very well tolerated with an overall incidence of adverse events of approximately 4%. Thus, roxithromycin is an attractive therapeutic alternative in its established indications, especially when the option of once-daily administration is considered.
Roxithromycin. An update of its antimicrobial activity ... - PubMed
Roxithromycin is very well tolerated with an overall incidence of adverse events of approximately 4%. Thus, roxithromycin is an attractive therapeutic alternative in its established indications, especially when the option of once-daily administration is considered.
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