Somatic hypermutation - Wikipedia
Somatic hypermutation (or SHM) is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it (e.g. microbes). A major component of the process of affinity maturation , SHM diversifies B cell receptors used to recognize foreign elements ( antigens ) and allows the immune system to adapt its response to ...
Somatic Hypermutation - an overview | ScienceDirect Topics
Somatic hypermutation (SHM) is the incorporation of point mutations within the immunoglobulin V-region genes, which serve as the basis for affinity maturation and effective immune responses. The process is initiated by antigen stimulation, occurs in the dark zone of germinal centres, and requires functional AID [49] .
【科普】B细胞の养成之路（六） - 知乎 - 知乎专栏
在给大家介绍成熟B（也叫naive B）和naive T细胞的相互作用前，我们先来谈谈为B细胞多样性做了更多贡献的两个机理： 先说说somatic hypermutation。 它的原理如下： AID是一种酶，会把GC pair中的C通过酶的催化变成U，接下来会有两种结果： 如果U的错误被发现了，那么U会被UNG酶切掉，之后会有其他酶把这个缺口增大，同时一种error-prone的DNA polymerase会过来随意安一些base，而复制之后，一条是WT，另一条则会有一些突变。 接下来说说class-switch …
Levels of somatic hypermutations in B cell receptors increase …
Somatic hypermutation (SHM) is an important step in antigen-driven B cell development creating B lymphocytes expressing high-affinity antibody receptors. It is known that the peripheral B lymphocyte compartments of healthy children and adults differ ...
Somatic Hypermutation - ScienceDirect
2024年1月1日 · Somatic hypermutation (SHM) is a mechanism to introduce single base pair changes in the exons of the antibody gene that encode for the antibody variable region. Some of these mutations result in amino acid changes that modify the affinity of the antibody.
Somatic hypermutation - Latest research and news | Nature
2024年8月30日 · Somatic hypermutation is a process that allows B cells to mutate the genes that they use to produce antibodies. This enables the B cells to produce antibodies that...
Targeting of somatic hypermutation | Nature Reviews Immunology
2006年8月1日 · Somatic hypermutation (SHM) introduces mutations in the variable region of immunoglobulin genes at a rate of ∼ 10 −3 mutations per base pair per cell division, which is 10 6 -fold higher than...
Directed evolution using dCas9-targeted somatic hypermutation …
2016年10月31日 · Here, we develop CRISPR-X, a strategy to repurpose the somatic hypermutation machinery for protein engineering in situ. Using catalytically inactive dCas9 to recruit variants of cytidine...
Somatic Hypermutation of Immunoglobulin Genes - Cell Press
2002年4月19日 · Somatic hypermutation is critical for the generation of high-affinity antibodies and effective immune responses, but its molecular mechanism remains poorly understood. Recent studies have identified DNA strand lesions associated with the hypermutation process and suggested the involvement of specific repair molecules and pathways.
Somatic hypermutation and affinity maturation - Osmosis
Somatic hypermutation is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it (e.g. microbes), whereas affinity maturation refers to the process of increasing the specificity and strength of the interaction between an antibody and its target antigen to increase the effectiveness of the immune response.
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