Hereditary Spastic Paraplegia | National Institute of Neurological ...
Hereditary spastic paraplegia (HSP), also known as familial spastic paraparesis, refers to a group of inherited disorders that involves weakness and spasticity, which is stiffness of the legs. These symptoms get worse over time. Early in the disease, there …
Hereditary spastic paraplegia - Wikipedia
HSP is also known as hereditary spastic paraparesis, familial spastic paraplegia, French settlement disease, Strumpell disease, or Strumpell-Lorrain disease. The symptoms are a result of dysfunction of long axons in the spinal cord .
Hereditary spastic paraplegia | About the Disease | GARD
Hereditary spastic paraplegia (HSP) is a group of hereditary, degenerative, neurological disorders that primarily affect the upper motor neurons. Upper motor neurons in the brain and spinal cord deliver signals to the lower motor neurons, which in turn, carry messages to the muscles.
HSP & PLS - Spastic Paraplegia Foundation
Hereditary Spastic Paraplegia (HSP) is a group of rare, inherited neurological disorders. Their primary symptoms are progressive spasticity and weakness of the leg and hip muscles. Researchers estimate that some 90 different types of HSP …
Hereditary spastic paraplegia - UpToDate
2022年8月8日 · Hereditary spastic paraplegia (HSP) refers to a group of familial diseases that are characterized by progressive degeneration of the corticospinal tracts. Clinically, they present with lower limb spasticity and weakness.
Hereditary Spastic Paraplegia Overview - GeneReviews® - NCBI Bookshelf
2000年8月15日 · Hereditary spastic paraplegia (HSP) can be inherited in an autosomal dominant, autosomal recessive, or X-linked manner or by maternal (mitochondrial) inheritance, depending on the genetic subtype in a family.
Hereditary Spastic Paraplegia | HSP Support Group
Hereditary Spastic Paraplegia (HSP) is a diagnosis that covers a range of rare genetic disorders cased by one or more gene mutations. At present there are over 80 different types of HSP, with the gene mutation known for many of the types.
Hereditary spastic paraplegia: from diagnosis to emerging …
2019年7月31日 · Hereditary spastic paraplegia (HSP) describes a heterogeneous group of genetic neurodegenerative diseases characterised by progressive spasticity of the lower limbs. The pathogenic mechanism, associated clinical features, and imaging abnormalities vary substantially according to the affected gene and differentiating HSP from other genetic ...
Hereditary spastic paraplegia - NHS
Find out about hereditary spastic paraplegia (HSP), a rare group of inherited disorders that often cause weakness and stiffness in the leg muscles, which gradually gets worse over time.
What is HSP? - HSP Research Foundation
Hereditary Spastic Paraplegia (HSP) is a broad group of inherited, degenerative disorders characterised by impaired walking due to spasticity and weakness of the legs. The primary features of HSP are spasticity and weakness with the …
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