Tropisetron is recommended as six-day courses of 5 mg per day, given intravenously on Day 1 immediately before cancer chemotherapy, either as an infusion given over 15 minutes (see below for dilution instructions) or as a slow injection (not less than 1 minute), followed by oral administration on days 2 to 6.
注射用盐酸托烷司琼(瑞齐泰)详细说明书-注意事项-不良反应-用法 …
本品主要通过选择性地阻断外周神经元的突触前5-HT3受体而抑制呕吐反射，另外，其止吐作用也可能与其通过对中枢5-HT3受体的直接阻断而抑制最后区的迷走神经的刺激作用有关。 毒理研究遗传毒性:文献报道盐酸托烷司琼对小鼠骨髓微核无明显影响，体外高浓度也未见染色体畸变和致突变作用。 密封，在凉暗处保存。 有效期暂定24个月。
injection (not less than 1 minute), followed by oral administration on days 2 to 6. If tropisetron alone produces insufficient anti-emetic control, its therapeutic efficacy can be enhanced by dexamethasone. Capsules should be taken with water in the morning immediately upon rising, one hour before food intake.
妥立士宁说明书_医药百科_医库 - drugs.meditool.cn
1.预防和治疗癌症化疗引起的恶心和呕吐: 在任何化疗周期中，本品最多可应用6天①成人:推荐剂量为5mg/天。 推荐第一天采用静脉途径给药，以后改为口服给药，每天一次， 最多5天。 参照以下方法给药:第1天静脉给药:将本品5mg (1安瓿)溶于100毫升常用输注液中 (生理盐水、林格氏液或5%葡萄糖液)在化疗前快速静脉滴注 (15分钟以上);或缓慢静脉推注 (速度为2mg/min, 5mg/5ml. 的安瓿约3分钟注射完);或缓慢加入已有的静脉输液中。 第2~6天口服给药:每天一次口服给 …
Tropisetron: Uses, Interactions, Mechanism of Action - DrugBank …
Tropisetron is an indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.
TROPISETRON-AFT tropisetron (as hydrochloride) 5 mg/5 mL
2017年11月28日 · Tropisetron-AFT, solution for injection or infusion, contains tropisetron hydrochloride equivalent to either 2 mg or 5 mg tropisetron per ampoule. The pH of the solution is 4.6 – 5.2. The product also contains acetic acid, sodium acetate trihydrate, sodium chloride and water for injections.
Tropisetron-AFT is used to prevent nausea (feeling sick) and vomiting caused by surgery and by cancer chemotherapy. The active ingredient in Tropisetron-AFT is tropisetron. It works by stopping the action of a substance in the body called serotonin that is thought to cause the nausea and vomiting.
盐酸托烷司琼(Tropisetron hydrochloride) - 药物靶点：5-HT3 …
Tropisetron（5）可抑制5HT3受体上血清素的活性，从而抑制放疗和化疗引起的呕吐。 Vilazodone(6)是5HT-1A受体的部分激动剂，专门抑制中枢神经系统对血清素的再摄取。
TROPISETRON MYX tropisetron (as hydrochloride) 2 mg/2 mL
For the treatment and prevention of post-operative nausea and vomiting in adults (2 mg/2 mL ampoule only) Product summary: Visual Identification: A clear, colourless to very faintly yellow-brown aqueous solution; Container Type: Ampoule; Container Material: Glass Type I Clear; Container Life Time: 36 Months; Container Temperature: Store below ...
Pharmacokinetics of therapeutic doses of tropisetron in healthy ...
2000年12月12日 · Tropisetron is a potent and selective 5-HT 3 receptor antagonist, and it is used primarily in the treatment of patients with chemotherapy-induced or postoperative nausea and vomiting. Tropisetron is almost completely absorbed from the gastrointestinal tract, but undergoes dose-dependent first pass metabolism.