Uricosuric - Wikipedia
Uricosuric medications are substances that increase the excretion of uric acid in the urine, thus reducing the concentration of uric acid in blood plasma. In general, this effect is achieved by action on the proximal tubule of the kidney.
Pharmacologic urate-lowering therapy and treatment of tophi ... - UpToDate
2024年6月11日 · Management for the prevention of recurrent gout flares and damage to joints and other tissues from urate crystal deposition includes drug therapy, lifestyle modifications, and other strategies for risk reduction.
List of Antigout agents - Drugs.com
Antigout agents are also called antihyperuricemic agents. These agents work to either correct overproduction or underexcretion of uric acid. For the long term control of gout, hyperuricemia caused by formation of uric acid from purines, can be effectively controlled with these agents.
Uricosuric Agents - DrugBank Online
Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma. A platelet inhibitory and uricosuric agent used to inhibit thrombotic and embolic processes and to manage the chronic phases of gout .
Management of Gout: Update from the American College of …
• Allopurinol is the preferred urate-lowering agent, but HLA testing should be offered to patients of Southeast Asian or African American descent before starting to identify patients at risk for...
Urate-Lowering Therapy for the Prevention and Treatment of …
2017年3月17日 · Xanthene oxidase inhibitors (XOIs), including allopurinol and febuxostat, are first-line agents for the prevention of acute attacks. Probenecid, a uricosuric agent, is an appropriate adjunctive therapy or second-line agent when …
How Do Uricosuric Agents Work? - RxList
Uricosuric agents are medications prescribed for the treatment of gout, a painful arthritic condition caused by excessive uric acid in the blood that gets deposited as monosodium urate crystals in joints. Gout most commonly affects the big toes, but can also affect other joints such as ankles, knees, elbows, wrists, and fingers.
By definition a uricosuric agent is one that facilitates the renal excretion of uric acid presumably by specific inhibition of its tubular reabsorption and secretion.
Uricosuric medications for chronic gout - Cochrane
Uricosuric medications work to lower blood uric acid levels by increasing the amount of uric acid that is eliminated via the kidneys. Study characteristics. This summary of a Cochrane review presents what we know from research about the effect of …
Uricosuric drugs: the once and future therapy for hyperurice ... - LWW
This review considers the potential for uricosuric agents from the perspective of recent progress in the understanding of urate transport systems. Recent findings . No new agents have yet become available, but promising new drugs are under development.