X-inactivation - Wikipedia
X-inactivation (also called Lyonization, after English geneticist Mary Lyon) is a process by which one of the copies of the X chromosome is inactivated in therian female mammals. The inactive X chromosome is silenced by being packaged into a transcriptionally inactive structure called heterochromatin .
X Chromosome Inactivation | Learn Science at Scitable - Nature
X inactivation only occurs in cells with multiple X chromosomes, which explains why almost all calico cats are female. X inactivation exists in two different forms: random and imprinted.
3.3: X-inactivation - Biology LibreTexts
2021年12月14日 · X-inactivation is a random process that happens separately in individual cells during embryonic development. One cell might shut down the paternal X, while its next-door neighbor might shut down the maternal X instead.
X chromosome inactivation: recent advances and a look forward
X chromosome inactivation, the transcriptional inactivation of one X chromosome in somatic cells of female mammals, has revealed important advances in our understanding of development, epigenetic control, and RNA biology.
Lyonization - National Human Genome Research Institute
6 天之前 · Lyonization (also called X-inactivation) refers to the normal phenomenon in which one of the two X chromosomes in every cell of a female individual is inactivated during embryonic development. This inactivation prevents females from having twice as many X chromosome gene products as males, who possess only a single copy of the X chromosome.
X Chromosome Inactivation and Embryonic Stem Cells
Genetic studies in mice and humans with X-to-autosome translocations have revealed that a major X-linked control locus, the X inactivation center (Xic in mice and XIC in humans) is necessary for XCI to occur. 34-37 The Xic, which encompasses more then 1 Mb on the mouse X chromosome, 38 has been shown to contain at least 4 genes which are ...
X Inactivation and Escape: Epigenetic and Structural Features
A subset of genes escapes X inactivation, raising questions about mechanisms that preserve their expression despite being embedded within heterochromatin. Escape gene expression differs between males and females, which can lead to physiological sex differences.