Biotin Metabolism | Pathway - PubChem
2019年5月30日 · Biotin acts as a cofactor for enzymes to catalyze carboxylation reactions involved in gluconeogenesis, amino acid catabolism and fatty acid metabolism. Biotin deficiency has been associated with many human diseases.
Biotin in metabolism, gene expression, and human disease
Enzyme-bound biotin acts as a vector to transfer a carboxyl group between donor and acceptor molecules during carboxylation reactions. In recent years, evidence has mounted that biotin also regulates gene expression through a mechanism beyond its role as a …
Biotin - PMC - PubMed Central (PMC)
This review describes mammalian biotin metabolism, biotin analysis, markers of biotin status, and biological functions of biotin. Proteins such as holocarboxylase synthetase, biotinidase, and the biotin transporters SMVT and MCT1 play crucial roles in …
Biotin Metabolism - Basic Neurochemistry - NCBI Bookshelf
Biotin is a cofactor in two reactions involving amino acids: the carboxylation of 3-methylcrotonyl-CoA in the pathway of leucine catabolism and the carboxylation of propionyl-CoA to form methylmalonyl-CoA (Fig. 44-1).
[Importance of biotin metabolism] - PubMed
Biotin is a water soluble enzyme cofactor that belongs to the vitamin B complex. In humans, biotin is involved in important metabolic pathways such as gluconeogenesis, fatty acid synthesis, and amino acid catabolism by acting a as prosthetic group for pyruvate carboxylase, propionyl-CoA carboxylase, beta-methylcrotinyl-CoA carboxylase, and acetyl-CoA carboxylase.
Biotin in metabolism and its relationship to human disease
Biotin, a water-soluble vitamin, is used as cofactor of enzymes involved in carboxylation reactions. In humans, there are five biotin-dependent carboxylases: propionyl-CoA carboxylase; methylcrotonyl-CoA carboxylase; pyruvate carboxylase, and two forms of acetyl-CoA carboxylase.
Biotin in Metabolism and Its Relationship to Human Disease
2002年9月1日 · In this report, we review the different roles of biotin in cell metabolism and human disease and present our laboratory data showing that biotin acts through a signaling cascade that includes the soluble form of guanylate cyclase (sGC) and a …
Biotin Homeostasis and Human Disorders: Recent Findings and
2024年6月14日 · Biotin (vitamin B7, or vitamin H) is a water-soluble B-vitamin that functions as a cofactor for carboxylases, i.e., enzymes involved in the cellular metabolism of fatty acids and amino acids and in gluconeogenesis; moreover, as reported, biotin may be …
BIOTIN IN METABOLISM AND MOLECULAR BIOLOGY | Annual …
Although the metabolism and role of biotin in intermediary metabolism are well established, biotin remains one of the most poorly understood water-soluble vitamins in terms of nutritional requirements and responsiveness to physiological and pharmacological states.
Cell and Molecular Aspects of Human Intestinal Biotin Absorption
Protein-bound forms of biotin are digested to free biotin prior to absorption in the small intestine. Digestion is first performed by the action of gastrointestinal proteases and peptidases, leading to the generation of biocytin (biotinyl-L-lysine; Fig. 1 A ) and biotin-short peptides ( 25 ).