Insulin/IGF signaling and its regulation in Drosophila
2015年9月15日 · Taking advantage of Drosophila as a genetically tractable experimental animal much progress has been made in our understanding of how the insulin/IGF signaling (IIS) pathway regulates development, growth, metabolism, stress responses and lifespan.
Insulin signaling in Drosophila melanogaster mediates Aβ toxicity …
2019年1月8日 · Here, using Drosophila as a model system, we show that reducing insulin signaling can effectively suppress the toxicity from Aβ (Amyloid beta 42) expression. On the other hand, Aβ...
Drosophila as a Model for Diabetes and Diseases of Insulin …
We discuss features of metabolism and sugar regulation that are shared between flies and mammals, and specific Drosophila models for Type 1 and Type 2 diabetes, Metabolic syndrome, and related abnormalities including insulin resistance and heart disease.
Insulin/IGF signaling in Drosophila and other insects: factors that ...
Insulin, insulin-like growth factors (IGFs) and insulin-like peptides (ILPs) are important regulators of metabolism, growth, reproduction and lifespan, and mechanisms of insulin/IGF signaling (IIS) have been well conserved over evolution. In insects, between one and 38 ILPs have been identified in e …
Drosophila insulin‐like peptides: from expression to functions – a ...
2020年10月8日 · Insulin signaling pathway in Drosophila. Drosophila insulin-like peptides (DIPLs) bind to insulin receptors (InR), leading to receptor activation and autophosphorylation. Activated Drosophila InR (dInR) phosphorylates CHICO protein (i.e., the substrate of the insulin receptor) subsequently activates phosphoinositide-3-kinase (PI3K).
Structural conservation of insulin/IGF signalling axis at the insulin ...
2023年10月7日 · In Drosophila, this signalling engages seven insulin-like hormones (DILP1-7) and a single receptor (dmIR). This report describes the cryoEM structure of the dmIR ectodomain:DILP5 complex,...
Insulin/IGF signaling in Drosophila and other insects: factors that ...
2015年10月15日 · Insulin signaling, lifespan and stress resistance are modulated by metabotropic GABA receptors on insulin producing cells in the brain of Drosophila. PLoS ONE. 2010; 5 (12):e15780. doi: 10.1371/journal.pone.0015780.
Genetic analysis of insulin signaling in Drosophila
2002年5月1日 · Molecular and genetic analysis of the insulin signaling pathway in Drosophila has revealed striking conservation at both the structural and functional levels. Recent studies emphasize the central role of insulin in the coordinated regulation of growth, metabolism, reproduction and lifespan.
Genetic analysis of insulin signaling in Drosophila - PubMed
Studies in the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans have revealed that components of the insulin signaling pathway have been highly conserved during evolution. Genetic analysis in Drosophila suggests that structural conservation also extends to the functional lev …
A glucose-sensing neuron pair regulates insulin and glucagon in
2019年10月23日 · Here we identify a pair of glucose-sensing neurons with bifurcated axons in the brain of Drosophila. One axon branch projects to insulin-producing cells to trigger the release of Drosophila...