Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical …
2022年12月19日 · In this study, we found that LDHA binds to Rac1–GTP and inhibits its interaction with Rac1 GAPs, resulting in Rac1 activation independently of LDHA glycolytic enzyme activity to promote...
LDHA induces EMT gene transcription and regulates autophagy …
2021年4月1日 · Lactate dehydrogenase A (LDHA) is an enzyme that catalyzes the final step of the Warburg effect by converting the pyruvate and NADH to lactate. This leads to an acidic microenvironment for the tumor, contributing to epithelial–mesenchymal transition (EMT) and metastasis 10, 11.
Lactate dehydrogenase A regulates tumor-macrophage symbiosis …
2024年3月5日 · Combined profiling and functional studies demonstrate that lactate dehydrogenase A (LDHA)-directed extracellular signal-regulated kinase (ERK) pathway activates yes-associated...
Lactate dehydrogenase A: A key player in carcinogenesis and …
Lactate dehydrogenase A (LDHA) facilitates glycolytic process by converting pyruvate to lactate. Numerous researches demonstrate LDHA has an aberrantly high expression in multiple cancers, which is associated with malignant progression. In this review, we summarized LDHA function in cancer research.
KCNK1 promotes proliferation and metastasis of breast cancer
2024年6月21日 · KCNK1 binds to and activates LDHA, promotes lactate production, and catalyzes H3K18la modification of target genes in breast cancer cells, and also raises the level of histone lactylation modification of LDHA itself, which further sustained LDHA expression in a positive feedback loop.
Histone H3K18 and Ezrin Lactylation Promote ... - Wiley Online …
2024年5月20日 · To investigate the potential involvement of RhoA/ROCK signaling in LPS-stimulated HK-2 cells, we used western blotting to examine the expression and phosphorylation levels of myosin phosphatase target subunit 1 (MYPT1), the downstream target of …
The lactate dehydrogenase (LDH) isoenzyme spectrum enables
2023年3月24日 · Isoenzyme divergence is a prevalent mechanism governing tissue-specific and developmental stage-specific metabolism in mammals. The lactate dehydrogenase (LDH) isoenzyme spectrum reflects the tissue-specific metabolic status. We found that three tetrameric isoenzymes composed of LDHA and LDHB (LDH-3/4/5) comprise the LDH spectrum in T cells.
Development of human lactate dehydrogenase a inhibitors: high ...
2024年8月10日 · Lactate dehydrogenase A (LDHA) is highly expressed in many tumor cells and promotes the conversion of pyruvate to lactic acid in the glucose pathway, providing energy and synthetic precursors for rapid proliferation of tumor cells. Therefore, inhibition of LDHA has become a widely concerned tumor treatment strategy.
Novel Peptide Inhibitors for Lactate Dehydrogenase A (LDHA): …
2019年3月18日 · Lactate dehydrogenase A (LDHA) is a critical metabolic enzyme belonging to a family of 2-hydroxy acid oxidoreductases that plays a key role in anaerobic metabolism in...
The Regulation and Function of Lactate Dehydrogenase A: …
2015年8月13日 · Lactate dehydrogenase (LDH) is a tetrameric enzyme, belonging to the 2-hydroxy acid oxidoreductase family, which increases the rate of the simultaneous inter-conversion of pyruvate to lactate and nicotinamide adenine dinucleotide (NAD)H to NAD + by 14 orders of magnitude 10 (Figure 1).