Distinct roles for ROCK1 and ROCK2 in the regulation of cell
2013年2月7日 · This study, using mouse embryonic fibroblast (MEF) cells derived from ROCK1−/− and ROCK2−/− mice, is designed to dissect roles for ROCK1 and ROCK2 in …
ROCK1 functions as a suppressor of inflammatory cell migration …
2010年3月4日 · Increased recruitment of macrophages and neutrophils into the inflamed peritoneum of ROCK1 −/− mice. (A) Western blot analysis demonstrating the expression of …
The RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory …
We show here that ROCK1 and ROCK2 are similarly expressed in IMG cells and used an siRNA approach to downregulate both genes. ROCK1, ROCK2, and ROCK1+ROCK2 siRNA …
Nrf2 regulates cell motility through RhoA–ROCK1 signalling
2021年1月13日 · The expression levels of Nrf2, RhoA, Rock1, and/or EMT markers were detected using (a,c) western blotting or (b,d) qRT-PCR.
Identification of ROCK1 kinase as a critical regulator of Beclin1 ...
2013年7月23日 · Western blot analysis of ROCK1 expression in the heart tissue from three different genotypes using anti-ROCK1 antibody (bottom). β-Actin was used for protein loading …
Western blot analysis of the Rho/ROCK signaling pathway. (a) Western …
Additionally, this study illustrates how PTEN downregulates of the Rho A/Rho kinase (ROCK) pathway which when stimulated decreases the integrity of the mucosal barrier. ... ... This is …
Distinct roles for ROCK1 and ROCK2 in the regulation of cell …
2013年2月7日 · ROCK1−/− MEFs exhibited improved actin cytoskeleton stability characterized by attenuated periphery actomyosin ring formation and preserved central stress fibers, associated …
Structure of a Highly Conserved Domain of Rock1 Required for
2013年12月9日 · To dissect the mechanism of Rock function in this process, we utilized siRNA-mediated knock-down of canine Rock1 and Rock2. As demonstrated by western blotting, we …
Rho-associated kinase (ROCK) function is essential for cell ... - eLife
2016年1月14日 · Western Blot analysis revealed the retention of ROCK1 and 2 protein in tumors derived from Rock1 ∆/∆;Rock2 ∆/∆ (Trp53 DD; H-Ras V12) MEFs but complete deletion of …
Inhibition of ROCK1 kinase modulates both tumor cells and …
2017年8月25日 · Western blotting analysis showed robust expression among the PANC-1, Mia PaCa-2, and SU.86.86 cell lines, and relatively low expression among the BxPC3, AsPC-1, …