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Saquinavir (trade name Invirase) is a protease inhibitor, used to treat HIV (human immunodeficiency virus). a. Locate all stereogenic centers in saquinavir, and label each stereogenic center as R or S. b. Draw the enantiomer of saquinavir. c. Draw a diastereomer of saquinavir. d. Draw a constitutional isomer that contains at least one different functional group. | Numerade
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SOLVED:H I V protease inhibitor design. Compound A is one of a series that were designed to be potent inhibitors of HIV protease. Compound A was tested by using two assays: (1) direct inhibition of HIV protease in vitro and (2) inhibition of viral RNA production in HIV-infected cells, a measure of viral replication. The results of these assays are shown below. The HIV protease activity is measured with a substrate peptide present at a concentration equal to its KM value. Estimate the values for
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